Clinical indication(s) / Claim(s)
Verbatim per manufacturer's Instructions-for-use (IFU) sheet
Claim 1: Provides extra protection for teeth.
Claim 2: Helps neutralize acid challenges
Clinical evidence supporting the claim(s)
From full report(s) of prospective, clinical controlled trial(s)
Clinical evidence not supporting the claim(s)
From full report(s) of prospective, clinical controlled trial(s)
Clinical evidence not related to the claim(s)
From full report(s) of prospective, clinical controlled trial(s)
CQ-Score of the publication
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CQ-Score of the publication
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CQ-Score of the publication
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CQ-Score of the publication
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CQ-Score of the publication
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CQ-Score of the publication
Criterion I = 1 Criterion II = 0 Criterion III = 1 / Total score = 0
CQ-Score of the publication
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CQ-Score of the publication
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CQ-Score of the publication
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CQ-Score of the publication
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Claim 1:
Dehui ZHANG ,Xiaotao ZHANG ,Hong PENG ,Haitao SUN. Casein phosphopeptide-amorphous calcium phosphate nanocomplexes as a preventive agent for radiation caries and dental sensitivity in irradiated head and neck cancer patients. Chin J Clin Onco 2014; 41: 1293.
CHEN Yan, ZHOU Yan, QIN Yang-da, LI Shi-jian, JIANG Rong-lin, LI Min-dong, LU Qi-fang, ZHONG Xiu-fen. Prevention of radioactive caries in patients with nasopharyngeal carcinoma by local application of casein calcium phosphate compound tooth mousse. Chin J Cons Dent 2016; 26: 498.
Esenlik E, Uzer Çelik E, Bolat E. Efficacy of a casein phosphopeptide amorphous calcium phosphate (CPP-ACP) paste in preventing white spot lesions in patients with fixed orthodontic appliances: A prospective clinical trial. Eur J Paediatr Dent. 2016 Dec;17(4):274-280.
ZHU Yongcui,ZHAI Lei,SU Juanjuan,SHI Guanghui,JIA Jie,GUO Jing. Clinical effect of fluoride varnish and GC tooth mousse in inhibiting enamel demineralization during orthodontic treatment. J Modern Stoma 2018; 32: 152.
CAI Rong,wU Guo, ZHANG Xi ,FENG Yu-tao,WANG Yu-feng,CHEN Li-yan. A Comparison Study on Preventive Effect of Enamel Decalcification during Orthodontic Treatment between Fluorine Coating and GC Tooth Mousse. Med Pharm J Clin PLA 2016; 28: 70.
Katsura, K., Soga, M., Abe, E. et al. Effects of casein phosphopeptide-amorphous calcium phosphate with sodium fluoride on root surface conditions in head and neck radiotherapy patients. Oral Radiol 32, 105-110 (2016).
HE Wen-dan, LIU Ying-zhi, XU Yuan-yuan, CHEN Dong. Study on application of CPP-ACP on tooth mineralization during orthodontic treatment with fixed appliance. Shanghai J Stoma 2010; 19: 140.
Claim 2:
Akin M, Basciftci FA. Can white spot lesions be treated effectively? Angle Orthod. 2012 Sep;82(5):770-5.
Güçlü ZA, Alaçam A, Coleman NJ. A 12-Week Assessment of the Treatment of White Spot Lesions with CPP-ACP Paste and/or Fluoride Varnish. Biomed Res Int. 2016;2016:8357621.
Wang JX, Yan Y, Wang XJ. Clinical evaluation of remineralization potential of casein phosphopeptide amorphous calcium phosphate nanocomplexes for enamel decalcification in orthodontics. Chin Med J (Engl). 2012 Nov;125(22):4018-21.
Aykut-Yetkiner A, Kara N, Ates M, Ersin N, Ertugrul F. Does casein phosphopeptid amorphous calcium phosphate provide remineralization on white spot lesions and inhibition of Streptococcus mutans? J Clin Pediatr Dent. 2014 Summer;38(4):302-6.
Bailey DL, Adams GG, Tsao CE, Hyslop A, Escobar K, Manton DJ, Reynolds EC, Morgan MV. Regression of post-orthodontic lesions by a remineralizing cream. J Dent Res. 2009 Dec;88(12):1148-53.
Memarpour M, Fakhraei E, Dadaein S, Vossoughi M. Efficacy of fluoride varnish and casein phosphopeptide-amorphous calcium phosphate for remineralization of primary teeth: a randomized clinical trial. Med Princ Pract. 2015;24(3):231-7.
Krithikadatta J, Fredrick C, Abarajithan M, Kandaswamy D. Remineralisation of occlusal white spot lesion with a combination of 10% CPP-ACP and 0.2% sodium fluoride evaluated using Diagnodent: a pilot study. Oral Health Prev Dent. 2013;11(2):191-6.
Bakkal M, Abbasoglu Z, Kargul B. The Effect of Casein Phosphopeptide-Amorphous Calcium Phosphate on Molar-Incisor Hypomineralisation: A Pilot Study. Oral Health Prev Dent. 2017;15(2):163-167.
NIE Lin,LI Jialing,MA Qiaoling,SHENG Zuli,LI Shipei.Clinical study on remineralizing effect of CPP-ACP on enamel demineralization after orthodontic treatment. Stomatol 2015; 35: 948.
Claim 1:
Sim CP, Wee J, Xu Y, Cheung YB, Soong YL, Manton DJ. Anti-caries effect of CPP-ACP in irradiated nasopharyngeal carcinoma patients. Clin Oral Investig. 2015 Jun;19(5):1005-11.
Sitthisettapong T, Phantumvanit P, Huebner C, Derouen T. Effect of CPP-ACP paste on dental caries in primary teeth: a randomized trial. J Dent Res. 2012 Sep;91(9):847-52.
Plonka KA, Pukallus ML, Holcombe TF, Barnett AG, Walsh LJ, Seow WK. Randomized controlled trial: a randomized controlled clinical trial comparing a remineralizing paste with an antibacterial gel to prevent early childhood caries. Pediatr Dent. 2013 Jan-Feb;35(1):8-12.
Pukallus ML, Plonka KA, Holcombe TF, Barnett AG, Walsh LJ, Seow WK. A randomized controlled trial of a 10 percent CPP-ACP cream to reduce mutans streptococci colonization. Pediatr Dent. 2013;35(7):550-5.
Claim 2:
Shell E. Effectiveness of Mi PasteTM, Mi Paste PlusTM, and Topex RenewTM in remineralization and visible reduction of white spot lesions after orthodontic treatment - a clinical study. Thesis; 2012.
Biondi AM, Cortese SG, Babino L, Fridman DE. Comparison of Mineral Density in Molar Incisor Hypomineralization applying fluoride varnishes and casein phosphopeptide-amorphous calcium phosphate. Acta Odontol Latinoam. 2017 Dec;30(3):118-123.
Sitthisettapong T, Doi T, Nishida Y, Kambara M, Phantumvanit P. Effect of CPP-ACP Paste on Enamel Carious Lesion of Primary Upper Anterior Teeth Assessed by Quantitative Light-Induced Fluorescence: A One-Year Clinical Trial. Caries Res. 2015;49(4):434-41.
Bröchner A, Christensen C, Kristensen B, Tranæus S, Karlsson L, Sonnesen L, Twetman S. Treatment of post-orthodontic white spot lesions with casein phosphopeptide-stabilised amorphous calcium phosphate. Clin Oral Investig. 2011 Jun;15(3):369-73.
Karabekiroglu S, Ünlü N, Küçükyilmaz E, Sener S, Botsali MS, Malkoç S. Treatment of post-orthodontic white spot lesions with CPP-ACP paste: A three year follow up study. Dent Mater J. 2017 Nov 29;36(6):791-797.
Llena C, Leyda AM, Forner L. CPP-ACP and CPP-ACFP versus fluoride varnish in remineralisation of early caries lesions. A prospective study. Eur J Paediatr Dent. 2015 Sep;16(3):181-6.
Singh S, Singh SP, Goyal A, Utreja AK, Jena AK. Effects of various remineralizing agents on the outcome of post-orthodontic white spot lesions (WSLs): a clinical trial. Prog Orthod. 2016 Dec;17(1):25.
